Cobertura de la vacunación contra la influenza entre embarazadas - Temporada de influenza 2016-17 en Estados Unidos
Semanal / 29 de septiembre del 2017 / 66(38);1016-1022
Datos del artículo
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Helen Ding, MD1; Carla L. Black, PhD1; Sarah Ball, ScD2; Rebecca V. Fink, MPH2; Walter W. Williams, MD1; Amy Parker Fiebelkorn, MSN, MPH1; Peng-Jun Lu, MD, PhD1; Katherine E. Kahn, MPH1; Denise V. D’Angelo, MPH3; Rebecca Devlin, MA2; Stacie M. Greby, DVM1 (ver las afiliaciones de los autores)Ver la referencia bibliográfica sugerida
¿Qué se sabe sobre este tema?
Pregnant women and infants are at increased risk for influenza-related complications and hospitalization. Vaccinating pregnant women can reduce their risk for influenza-related respiratory illness and reduce the risk for influenza in their infants aged <6 months. A provider recommendation for and offer of vaccination is associated with higher vaccination coverage among pregnant women.
¿Qué información agrega este informe?
Analysis of data from a 2017 Internet panel survey indicates that in the 2016-17 influenza season, 53.6% of pregnant women were vaccinated before or during pregnancy, similar to the 2015-16 season. Prevalence of provider recommendation for and offer of vaccination were similar to those in the last four influenza seasons. Most women who reported receiving both a provider recommendation for and offer of influenza vaccination had high vaccination coverage (70.5%), but this varied for those with public insurance (63.9%) and by other sociodemographic factors.
¿Cuáles son las consecuencias para la práctica de salud pública?
To improve protection from complications of influenza for mothers and infants, measures to improve vaccination coverage are needed. Implementing the Standards for Adult Immunization Practice, which recommend all health care providers assess, recommend, administer or refer, and document vaccinations, can help ensure pregnant women are fully vaccinated. Evidence-based practices such as provider reminders and standing orders can help implement these standards and reduce missed opportunities for vaccination.
Pregnant women and their infants are at increased risk for severe influenza-associated illness (1), and since 2004, the Advisory Committee on Immunization Practices (ACIP) has recommended influenza vaccination for all women who are or might be pregnant during the influenza season, regardless of the trimester of the pregnancy (2). To assess influenza vaccination coverage among pregnant women during the 2016–17 influenza season, CDC analyzed data from an Internet panel survey conducted during March 28–April 7, 2017. Among 1 893 survey respondents pregnant at any time during October 2016–January 2017, 53.6% reported having received influenza vaccination before (16.2%) or during (37.4%) pregnancy, similar to coverage during the preceding four influenza seasons. Also similar to the preceding influenza season, 67.3% of women reported receiving a provider offer for influenza vaccination, 11.9% reported receiving a recommendation but no offer, and 20.7% reported receiving no recommendation; among these women, reported influenza vaccination coverage was 70.5%, 43.7%, and 14.8%, respectively. Among women who received a provider offer for vaccination, vaccination coverage differed by race/ethnicity, education, insurance type, and other sociodemographic factors. Use of evidence-based practices such as provider reminders and standing orders could reduce missed opportunities for vaccination and increase vaccination coverage among pregnant women.*
Since 2011, an Internet panel survey has been conducted for CDC by Abt Associates, Inc. (Cambridge, Massachusetts) at the beginning of each April to provide end-of-season estimates of influenza vaccination coverage among pregnant women and assess factors associated with vaccination. The Internet panel† and survey methodology have been described previously (3). The 2016–17 survey was conducted during March 28–April 7, 2017, among women aged 18–49 years who reported being pregnant at any time since August 1, 2016. Among 10 734 women who entered the survey site, 2 399 were eligible and 2 319 completed the survey (a cooperation rate of 96.7%).§ Data were weighted to reflect the age, race/ethnicity, and geographic distribution of the total U.S. population of pregnant women. A woman was considered to be vaccinated for the 2016–17 season if she reported receiving vaccination before or during her most recent pregnancy since July 1, 2016. Analysis was limited to 1 893 women who reported being pregnant any time during the peak influenza vaccination period (October 2016–January 2017). A difference was noted as an increase or decrease when a ≥5 percentage-point difference occurred between any values being compared.¶
Influenza vaccination coverage among pregnant women in 2016–17 was similar to coverage during the previous four seasons (imagen). Among women pregnant during the 2016–17 influenza season, 53.6% reported receiving influenza vaccination before (16.2%) or during (37.4%) pregnancy since July 1, 2016 (Tabla 1). Coverage among women aged 18-24 years (41.7%) was lower than coverage among women aged 25-34 years (58.4%) and 35-49 years (58.5%). Coverage among Hispanic women (61.2%) was higher than that among non-Hispanic white (white) women (55.4%) and non-Hispanic black (black) women (42.3%); these differences were not observed during the 2015-16 season. Higher vaccination coverage was found among women with higher level of education, married women, women with private or military insurance, working women, women at or above poverty level, women with a high-risk condition, women with positive attitude toward vaccination effectiveness or safety, and women who were concerned about influenza infection, similar to the 2015-16 season.
The proportion of women who reported receiving a provider recommendation for and offer** of vaccination was 67.3% in the 2016–17 season, similar to that during the past four seasons (Figure). During both the 2015–16 and 2016–17 seasons, women who reported receiving both a provider recommendation for and offer of influenza vaccination had higher vaccination coverage (63.4% [2015–16] and 70.5% [2016–2017]) compared with women who reported receiving a provider recommendation but no offer†† (37.5% and 43.7%) and women who reported receiving no recommendation for vaccination§§ (12.8% and 14.8%) (Table 1); this pattern was observed among all age groups, racial/ethnic groups, levels of education, marital status, some level of insurance coverage, poverty status, number of health care visits, presence or absence of a high-risk condition, attitudes regarding efficacy and safety of influenza vaccine, and concern about influenza infection (Tabla 2). An increased number of provider visits since July 2016 was associated with both an increase in women's report of receiving a provider recommendation and an increase in vaccination coverage estimates (65.7% [1-5 visits]; 70.9% [6-10 visits]; 72.1% [>10 visits]). Women in the following subgroups reported receiving a provider recommendation for and offer of vaccination less frequently than did women in the reference category of each stratum: aged 18-24 years, with a college degree, without medical insurance, without a high-risk condition other than pregnancy, with a negative attitude toward influenza vaccination effectiveness or safety, or not concerned about influenza infection (Table 2).
Vaccination coverage differed within some subgroups that reported similar proportions of receipt of a provider recommendation for and offer of vaccination. For example, although 68%-69% of insured women reported being offered vaccination, coverage was 74.7% among women with private or military insurance and 63.9% among women with public insurance. Differences in coverage among women who were offered vaccination were also observed between white and black women and women with more than a college degree and those with a college degree or less (Table 2). Among insured women who were offered vaccination, a higher proportion of publically insured women were younger (18-24 years), black, had less than a college degree, and lived below the poverty threshold compared with privately insured women.
Among the 221 (11.9%) women who reported that their provider recommended but did not offer vaccination, 114 (51%) received a referral¶¶ to go somewhere else to be vaccinated; 36.7% of the women receiving a referral were vaccinated, compared with only 12.5% of women who received a provider recommendation but no offer or referral.
Influenza vaccination coverage among pregnant women in 2016–17 was 53.6%, similar to coverage in the 2012–13 through 2015–16 influenza seasons. Similar to the past three seasons, 67.3% of pregnant women in 2016–17 reported receiving a provider recommendation for and offer of vaccination. Although the Standards for Adult Immunization Practice (4) support recommendation for and offer of influenza vaccination, the percentage of currently or recently pregnant women who reported receiving a provider recommendation and offer has not changed during the last four influenza seasons. This might be partly attributable to differences in perception among patients and providers of a recommendation for or offer of vaccination. In a recent survey of obstetric care providers conducted by the American College of Obstetricians and Gynecologists (ACOG), all surveyed providers reported that they recommend influenza vaccine to their pregnant patients; however, only 85% of patients surveyed at the same practices reported receiving a recommendation for vaccination, suggesting that although providers believe they are giving a recommendation for vaccination, the recommendation might not be communicated effectively (5).
Vaccination differences were seen by race/ethnicity, concerns about vaccination and influenza, insurance status, and number of provider visits. As has previously been observed, black women had lower vaccination coverage and Hispanic women had higher vaccination coverage compared with white women, despite similar percentages among each racial/ethnic group reporting a provider recommendation for and offer of vaccination (3). One study found that racial differences in vaccination coverage among pregnant women persisted after adjustment for a provider recommendation for or offer of influenza vaccination, insurance status, and demographic factors (6), and another study suggests that racial disparities might be caused by differences in sociocultural norms, misperception of effectiveness and safety of vaccination, and vaccination resistance and hesitancy (7), or could be modified or confounded by other factors such as age, education, or insurance status.
Although many women reported concerns about the safety or effectiveness of vaccination, these women were more likely to be vaccinated when there was a provider recommendation and offer compared with women with vaccination concerns who did not receive a vaccination recommendation from their provider, underscoring the need for providers to educate and counsel all pregnant patients. Although vaccination coverage increased with number of provider visits, 37% of women who had more than 10 visits were not vaccinated, indicating missed vaccination opportunities. Assessing vaccination status at every clinical encounter and providing an effective recommendation for and offer of vaccination can help ensure that more pregnant women receive influenza vaccine during pregnancy (4). ACOG has developed a toolkit to assist providers in integrating vaccination services and effective recommendations into their practice, including communication strategies and other resources.***
In this report, vaccination coverage was lower among pregnant women with public health insurance than among those with private or military insurance, at each level of provider recommendation for or offer of vaccination; frequency of provider recommendation or offer was similar for women with public and private or military insurance. This was also found among women with less than a college degree compared with women with more than a college degree. Lower vaccination coverage has been reported among pregnant women with public insurance (8) and women with lower levels of education (3).††† Further work is needed to understand and address barriers to receipt of influenza vaccination by pregnant women covered by public insurance and with less than a college degree.
Los resultados de este informe están sujetos al menos a cuatro limitaciones. First, a nonprobability sample that did not include women without Internet access was used in the analysis; therefore, results are not generalizable to all pregnant women in the United States. Second, vaccination status was self-reported and might be subject to recall bias or social desirability bias. Third, because the Internet panel survey is an opt-in survey, estimates might be biased if a woman’s decision to join the internet panel or participate in this particular survey were related to receipt of vaccination. Vaccination coverage estimates from the Internet panel survey have been consistently 5–10 percentage points higher than estimates from the less timely probability-based National Health Interview Survey. However, both surveys have found similar stable trends with no increasing coverage.§§§ Strengths and limitations of the Internet panel survey compared with probability sampling surveys can be found elsewhere (9). Finally, the composite variables computed for attitudes toward influenza vaccination and infection were not validated.
Findings in this report support evidence that a provider’s recommendation for and offer of influenza vaccination to pregnant women is associated with receipt of vaccination. Women who were referred to another provider for vaccination were more likely to be vaccinated than women who did not receive an offer or referral. The Standards for Adult Immunization Practices call for all providers to strongly recommend needed vaccines and either administer vaccines or refer patients to a provider who can administer them (4). ACOG and Text4Baby¶¶¶ provide resources to ensure recommendations are provided effectively to help women receive influenza vaccination as early as possible during pregnancy. Vaccination coverage of pregnant women can be increased by a combination of 1) implementation of evidence-based practices (e.g., provider reminders and standing orders for vaccination) to ensure that influenza vaccination is recommended and offered at each visit before and during pregnancy or that the patient is referred to an influenza vaccine provider, and 2) clinical education about the risk for influenza infection and safety and benefit of influenza vaccination (10). Further work is needed to understand differences in vaccination coverage among women who were offered vaccination by a provider.
Conflicto de intereses
No se reportaron conflictos de intereses.
Corresponding author: Helen Ding, email@example.com, 404-639-8513.
1Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC; 2Abt Associates, Inc., Cambridge, Massachusetts; 3Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, CDC.
* Guide to Community Preventive Services: Vaccination; https://www.thecommunityguide.org/topic/vaccination.
† Additional information on the online survey and incentives for participants is available at https://www.surveysampling.com.
§ An opt-in Internet panel survey is a nonprobability sampling survey. El denominador para el cálculo de la tasa de respuesta no se puede determinar porque no hay un marco de muestreo con probabilidades de selección en la etapa de reclutamiento. En su lugar, se ofrece la tasa de cooperación de las encuestas.
¶ Additional information on obstacles to inference in nonprobability samples is available at http://www.aapor.org/Education-Resources/Reports/Non-Probability-Sampling.aspx.
** “Recommendation and offer” is based on a “yes” response to the question “Since July 2016, during any of your visits to a doctor, nurse, or medical professional, did any of these medical professionals offer to give you a flu vaccination during a visit?”
†† “Recommendation but no offer” is based on a “yes” response to the question “Since July 2016, during any of your visits to a doctor, nurse, or other medical professional, did any of these medical professionals recommend that you get a flu vaccination or tell you that you needed a flu vaccination?” and a “no” response to the question “Since July 2016, during any of your visits to a doctor, nurse, or medical professional, did any of these medical professionals offer to give you a flu vaccination during a visit?”
§§ “No recommendation” is based on a “no” response to the questions “Since July 2016, during any of your visits to a doctor, nurse, or other medical professional, did any of these medical professionals recommend that you get a flu vaccination or tell you that you needed a flu vaccination?” and “Since July 2016, during any of your visits to a doctor, nurse, or medical professional, did any of these medical professionals offer to give you a flu vaccination during a visit?”
¶¶ Referral is defined based on a “yes” response to the question “Did any doctor, nurse, or medical professional suggest that you go someplace else to get the flu vaccination?”
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- Ding H, Black CL, Ball S, et al. Influenza vaccination coverage among pregnant women-United States, 2014-15 influenza season. MMWR Morb Mortal Wkly Rep 2015;64:1000-5. CrossRef PubMed
- Orenstein WA, Gellin BG, Beigi RH, et al. ; National Vaccine Advisory Committee. Recommendations from the National Vaccine Advisory committee: standards for adult immunization practice. Public Health Rep 2014;129:115-23. CrossRef PubMed
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- Kennedy ED, Ahluwalia IB, Ding H, Lu P-J, Singleton JA, Bridges CB. Control de la cobertura de vacunación contra la influenza estacional entre embarazadas en Estados Unidos. Am J Obstet Gynecol 2012;207(Suppl):S9-16. CrossRef PubMed
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FIGURE. Prevalence of provider recommendation for and offer of influenza vaccination* and influenza vaccination coverage† among women pregnant any time during October–January — Internet panel survey, United States, 2010–11 through 2016–17 influenza seasons
* Entre las mujeres que reportaron haber hecho al menos una consulta a un proveedor desde julio.
† Vaccination coverage estimates for the 2012−13 through 2016−17 influenza seasons were based on vaccination given from July to mid-April; coverage estimates for the 2010−11 and 2011−12 influenza seasons were based on vaccination given from August to mid-April.
The figure above is a combination bar and line graph showing the prevalence of provider recommendation for and offer of influenza vaccination and influenza vaccination coverage among women pregnant any time during October–January in the United States, based on Internet panel survey data from the 2010–11 through 2016–17 influenza seasons.
TABLE 1. Influenza vaccination coverage before and during pregnancy among women pregnant any time during October−January, by selected characteristics — Internet panel surveys, United States, 2016−17 and 2015−2016 influenza seasons
|Características||temporada de influenza 2015-16||temporada de influenza 2016-17||Percentage point difference in vaccination coverage 2016–17 to 2015–16|
|Cant. no ponderada||% ponderado||Vaccinated, weighted %||Cant. no ponderada||% ponderado||Vaccinated, weighted %|
|Total||1 692||—||49.9||1 893||—||53.6||3.7|
|Vaccinated before pregnancy||239||—||14.1||292||—||16.2||2.1|
|Vaccinated during pregnancy||605||—||35.8||750||—||37.4||1.6|
|Grupo de edad (años)|
|De color, no hispanos||277||19.8||49.4||262||20.8||42.3*||(7.1)†|
|White, non-Hispanic§||898||50.4||49||1 200||50.2||55.4||6.4†|
|Otros, no hispanos||151||7.7||52.1||174||7.5||51.7||(0.4)|
|Yes§||1 044||59.8||53.5||1 386||70.2||56.7||3.2|
|Cobertura de seguros|
|Private/Military only§||983||56.6||53.5||1 250||63||59.3||5.8†|
|At or above poverty§||1 312||76.4||52||1 688||88.2||55.1||3.2|
|Number provider visits since July|
|Recommended and offered§||1 133||67.6||63.4||1 238||67.3||70.5||7.1†|
|Recommended with no offer||218||12.5||37.5*||221||11.9||43.7*||6.2†|
|Attitude toward effectiveness of influenza vaccination***|
|Positive§||1 313||77.9||61.8||1 473||77.8||65.8||4|
|Attitude toward safety of influenza vaccination†††|
|Positive§||1 265||74.6||62.8||1 467||75.4||66.9||4.1|
|Attitude toward influenza infection§§§|
|Concerned§||1 059||62.9||54||1 231||64.6||58.8||4.7|
TABLE 2. Percentage of women receiving a provider recommendation/offer of influenza vaccination and self-reported influenza vaccination coverage, by provider recommendation and offer among women who visited a provider at least once since July 2016 and who were pregnant any time during October 2016–January 2017 — Internet Panel Survey, United States, 2016–17 influenza season
|Características||Provider recommendation for/offer of influenza vaccination||Vaccination coverage|
|Cant. no ponderada||Recommended, offered,
|Recommended, no offer,
|Provider recommended, offered||Provider recommended, no offer||No recommendation|
|Cant. no ponderada||% ponderado||Cant. no ponderada||% ponderado||Cant. no ponderada||% ponderado|
|Total||1 822||67.3||11.9||20.7||1 238||70.5||221||43.7||363||14.8|
|Grupo de edad (años)|
|De color, no hispanos||216||64.4||12.3||23.3||137||64.9*||25||─§||54||9.8|
|White, non-Hispanic†||1 180||67.7||13||19.3||807||70.8||153||44.6||220||13.6|
|Otros, no hispanos||172||64.1||12.2||23.7||113||65.7||20||─§||39||16.6|
|Cobertura de seguros|
|Private/Military only†||1 221||68.3||12.8||18.9||847||74.7||163||48.7||211||17.8|
|At or above poverty†||1 624||66.7||12.3||21||1 099||73||203||46.9||322||14.5|
|Number of provider visits since July 2016|
|Attitude toward efficacy of influenza vaccination§§|
|Positive†||1 430||72||11.4||16.7||1 037||80.5||164||54.5||229||22.4|
|Attitude toward safety of influenza vaccination¶¶|
|Positive†||1 421||73.8||11.6||14.6||1 047||80.4||169||56.3||205||22.6|
|Attitude toward influenza infection***|
Suggested citation for this article: Ding H, Black CL, Ball S, et al. Influenza Vaccination Coverage Among Pregnant Women — United States, 2016–17 Influenza Season. Informe Semanal de Morbilidad y Mortalidad (MMWR) 2017;66:1016–1022. DOI: http://dx.doi.org/10.16/mmwr.mm6638a2.
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